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Vitamin E TPGS (Tocofersolan) Suppliers and Factory in China - High-Quality Water-Soluble Surfactant
C33H54O5·(C2H4O)n
Description
Vitamin E TPGS (D-α-tocopherol polyethylene glycol 1000 succinate) is a water-soluble vitamin E derivative, which is formed by combining natural vitamin E (α-tocopherol) and polyethylene glycol (PEG) through a succinate bond. Its unique molecular structure gives it excellent amphiphilicity, which is compatible with fat-soluble substances and soluble in water, making it a highly efficient functional excipient and active ingredient in the fields of nutrition, health care and pharmaceutical preparations.
Core Applications in the Field of Nutrition and Health Care
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Enhancing the Absorption of Fat-Soluble Nutrients
As a natural emulsifier, vitamin E TPGS can significantly improve the bioavailability of fat-soluble nutrients (such as coenzyme Q10, carotenoids, fish oil, etc.). Its micelle-forming ability helps these ingredients to be stably dispersed in the intestine and promotes absorption in the small intestine, which is especially suitable for people with weak digestive function (such as the elderly or postoperative patients). Studies have shown that TPGS can increase the absorption rate of certain fat-soluble ingredients by 2-5 times.
📆 TPGS can increase the absorption rate of certain fat-soluble ingredients by 2–5 times.
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Antioxidant and Immune Support
TPGS retains the strong antioxidant properties of vitamin E, can effectively remove free radicals, protect cell membranes from oxidative damage, and synergistically enhance immunity. Its water-soluble characteristics break through the traditional vitamin E absorption limitations, can directly reach the cellular aqueous environment, and achieve more efficient antioxidant defense, which is suitable for anti-aging, cardiovascular health and sports nutrition formulas.
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Special Dietary Supplement Carriers
TPGS is widely used in oral nutritional supplements (ONS) and medical foods to improve the delivery efficiency of fat-soluble vitamins (A, D, E, K), while improving product stability and avoiding stratification or degradation.
Innovative Value in the Pharmaceutical Field
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Drug Solubilization and Synergism
As an FDA-approved pharmaceutical excipient (GRAS certification), TPGS can improve the solubility and bioavailability of poorly soluble drugs, such as antifungal drugs (itraconazole) and anti-tumor drugs (paclitaxel). Its micelle encapsulation technology can reduce drug dosage and reduce liver and kidney toxicity.
✅ FDA-approved pharmaceutical excipient with GRAS certification.
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Targeted Delivery and Toxicity Reduction
In anti-tumor nanoformulations, TPGS as a carrier material can prolong drug circulation time, enhance tumor tissue permeability, and reverse multidrug resistance by inhibiting the function of P-glycoprotein efflux pump. Studies have shown that TPGS-modified nanoparticles can improve the efficacy of chemotherapy drugs by more than 50%, while reducing side effects such as hair loss and nausea.
📆 TPGS-modified nanoparticles can improve the efficacy of chemotherapy drugs by more than 50%.
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Development of New Delivery Systems
TPGS performs well in oral solid dispersions, self-microemulsification preparations and transdermal drug delivery systems, helping the development of sustained-release, enteric-coated or topical drug delivery products and expanding the possibility of innovative drugs.
Frequently Asked Questions (FAQ)
Q
What is Vitamin E TPGS and how is it different from regular Vitamin E?
Vitamin E TPGS (D-α-tocopherol polyethylene glycol 1000 succinate) is a water-soluble derivative of natural vitamin E formed by esterifying α-tocopherol succinate with polyethylene glycol 1000. Unlike regular vitamin E, which is fat-soluble and has limited bioavailability, TPGS is amphiphilic — meaning it is compatible with both water and fat — enabling significantly enhanced absorption and broader application in nutritional and pharmaceutical formulations.
Q
How does Vitamin E TPGS improve the bioavailability of fat-soluble nutrients?
TPGS acts as a natural emulsifier and forms micelles in the gastrointestinal tract. These micelles encapsulate fat-soluble nutrients such as coenzyme Q10, carotenoids, and omega-3 fatty acids, allowing them to be stably dispersed in the intestinal fluid and efficiently absorbed through the small intestine. Research indicates TPGS can increase the absorption rate of certain fat-soluble ingredients by 2 to 5 times compared to standard formulations.
Q
Is Vitamin E TPGS safe for use in pharmaceutical and food applications?
Yes. Vitamin E TPGS is recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and is widely accepted as a pharmaceutical excipient. It is used in approved drug formulations, oral nutritional supplements, and medical foods globally. Its excellent safety profile makes it suitable for sensitive populations, including the elderly, postoperative patients, and individuals with compromised digestive function.
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What role does Vitamin E TPGS play in anti-tumor drug delivery?
In anti-tumor nanoformulations, TPGS serves as a carrier material that prolongs drug circulation time in the bloodstream and enhances permeability into tumor tissues. Notably, TPGS can inhibit the P-glycoprotein efflux pump, reversing multidrug resistance in cancer cells. Studies have demonstrated that TPGS-modified nanoparticles can enhance the efficacy of chemotherapy drugs such as paclitaxel by more than 50%, while simultaneously reducing adverse side effects like nausea and hair loss.
Q
In what types of drug delivery systems is Vitamin E TPGS commonly used?
Vitamin E TPGS is a versatile excipient compatible with multiple advanced drug delivery platforms, including oral solid dispersions, self-microemulsifying drug delivery systems (SMEDDS), transdermal drug delivery systems, sustained-release formulations, and enteric-coated preparations. Its ability to solubilize poorly water-soluble drugs makes it especially valuable in developing next-generation innovative drug products.
Q
Can Vitamin E TPGS be used in sports nutrition and anti-aging products?
Absolutely. Vitamin E TPGS retains the powerful antioxidant properties of natural vitamin E, effectively neutralizing free radicals and protecting cell membranes from oxidative stress. Its water-soluble nature allows it to reach the cellular aqueous environment directly, delivering more efficient antioxidant defense than conventional fat-soluble vitamin E. This makes it an ideal ingredient for anti-aging, cardiovascular health, immune support, and sports nutrition formulas.