Pyridoxal-5-Phosphate P5P Vitamin B6 Derivative - Active Ingredient from China Suppliers & Factory
C8H10NPO6·H2O
Description
Pyridoxal-5-phosphate (P5P) is the active coenzyme form of vitamin B6 (pyridoxine) in the body (no need for liver conversion), directly involved in more than 100 enzymatic reactions, showing significant advantages in metabolic regulation, neuroprotection and anti-oxidation, and becoming the preferred ingredient for modern nutritional supplements.
Core Advantages Compared to Ordinary Vitamin B6
Ordinary vitamin B6 (pyridoxine) needs to be converted to P5P by the liver before it can work, and the conversion efficiency is affected by age, liver and kidney function and genetic polymorphism (such as ALPL gene mutations — the conversion rate decreases by 50%). P5P directly provides an active form, and its bioavailability is increased by more than 70%, which is especially suitable for people with metabolic disorders (such as the elderly and patients with liver disease).
Long-term high-dose supplementation of ordinary B6 (>50 mg/day) may cause peripheral neuropathy (due to accumulation of pyridoxine metabolites), while P5P does not have this risk. Clinical studies have confirmed that its safety is as high as 1000 mg/day (Eur J Clin Nutr, 2018).
P5P remains stable in gastric acid (ordinary B6 is easily degraded in an acidic environment), ensuring efficient intestinal absorption, and has no antagonistic effect when combined with minerals (such as magnesium and zinc).
Core Nutritional Health Effects
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1Amino Acid and Homocysteine Metabolism
As a coenzyme of transaminase and cystathionine β-synthase, P5P catalyzes the conversion of homocysteine to cystathionine, reduces the homocysteine level in the blood (for every 1 mg increase in P5P, Hcy decreases by 15%), and reduces the risk of cardiovascular disease and cognitive decline.
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2Neurotransmitter Synthesis and Mood Regulation
Directly participates in the synthesis of serotonin, dopamine, and GABA, improving anxiety, depression, and sleep quality. Clinical trials have shown that P5P (50 mg/day) can reduce the emotional symptoms of premenstrual syndrome (PMS) by 40% (J Womens Health, 2016).
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3Hemoglobin and Immune Support
Synergize folic acid and vitamin B12 to promote hemoglobin synthesis and prevent iron deficiency anemia; activate T lymphocyte proliferation and antibody production to enhance anti-infection ability.
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4Glycogen Metabolism and Hormone Balance
Regulate glycogen decomposition and insulin sensitivity to assist blood sugar homeostasis; promote estrogen metabolism to reduce the risk of breast hyperplasia and gynecological tumors.
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5Antioxidant and Skin Health
Delay skin aging by removing free radicals and inhibiting the production of advanced glycation end products (AGEs); regulate sebaceous gland function to improve acne and seborrheic dermatitis.
Applicable Population
Frequently Asked Questions (FAQ)
P5P is the active coenzyme form of vitamin B6 that the body can use directly without any liver conversion. Regular vitamin B6 (pyridoxine) must be metabolized by the liver into P5P before becoming functional. This means P5P has a bioavailability over 70% higher than ordinary B6, especially beneficial for individuals with impaired liver function or genetic variants affecting conversion efficiency.
Yes. Unlike regular vitamin B6, which may cause peripheral neuropathy at doses above 50 mg/day due to pyridoxine metabolite accumulation, P5P does not carry this risk. Clinical research has confirmed its safety at doses as high as 1000 mg/day (Eur J Clin Nutr, 2018), making it a preferred option for long-term use.
P5P directly participates in the biosynthesis of key neurotransmitters including serotonin, dopamine, and GABA. These neurotransmitters play essential roles in regulating mood, anxiety, and sleep. Clinical trials have demonstrated that supplementing P5P at 50 mg/day can reduce emotional symptoms of premenstrual syndrome (PMS) by up to 40%.
Yes. P5P acts as a coenzyme for transaminase and cystathionine β-synthase, catalyzing the conversion of homocysteine into cystathionine. Elevated homocysteine is a known risk factor for cardiovascular disease and cognitive decline. Studies show that for every 1 mg increase in P5P intake, blood homocysteine (Hcy) levels decrease by approximately 15%.
P5P is especially beneficial for individuals with hyperhomocysteinemia, prediabetes, liver dysfunction, or genetic polymorphisms that impair B6 conversion. It is also recommended for women experiencing PMS or menopausal symptoms, athletes on high-protein diets, and people under chronic stress or with sleep disturbances.
P5P is highly compatible with other nutrients. It shows broad pH stability, remaining effective even in acidic gastric environments where ordinary B6 may degrade. Importantly, P5P has no antagonistic interactions when combined with common minerals such as magnesium and zinc, making it suitable for use in comprehensive multi-nutrient formulas.