Hot Products
0102030405
O-Phospho-L-threonine: Top China Suppliers & Factory for High-Quality Threoninium Dihydrogen Phosphate
C4H10NO6P
Description
L-O-phospho-threonine (O-Phospho-L-threonine, CAS No. 1114-81-4) is a phosphorylated derivative of threonine. By introducing a phosphate group, its biological activity and functional diversity are significantly enhanced, showing unique value in the field of nutrition and health care.
Technical Advantages Analysis
⚡
Signal Transduction Enhancement
As a biological signal molecule, the phosphate group activates the protein kinase cascade reaction, regulates cell metabolism, differentiation and stress adaptation. Its negative charge characteristics enhance the affinity with the target protein and improve the efficiency of signal transduction.
🔬
Metabolic Regulation Upgrade
Promote glycogen synthase phosphorylation and accelerate glycogen storage; synchronously activate the pyruvate dehydrogenase complex and optimize the efficiency of mitochondrial ATP generation.
🛡️
Stability Improvement
Phosphorylation modification enhances molecular polarity, improves water solubility and thermal stability, and broadens the application scenarios of formulation development.
Core Role of Nutrition and Health Care
🩹
1. Cell Repair and Regeneration
Wound Healing: Activate fibroblast proliferation, promote orderly deposition of collagen, and shorten the wound healing cycle.
Muscle Recovery: Reduce the level of creatine kinase after exercise and relieve delayed muscle soreness.
💪
2. Immune Empowerment
Lymphocyte Activation: Enhance T/B cell receptor signal transduction, increase antibody secretion and diversity.
Anti-inflammatory Regulation: Inhibit NF-κB pathway, reduce pro-inflammatory factors TNF-α, IL-6 secretion.
Neuroprotection — Antioxidant Barrier: Upregulate glutathione peroxidase activity and scavenge free radicals.
Synaptic Plasticity: Promote brain-derived neurotrophic factor (BDNF) synthesis and maintain neuronal network stability.
🏃
3. Sports Nutrition Support
Energy Optimization: Improve muscle cell glycolysis efficiency and prolong exercise endurance.
Lactic Acid Metabolism: Accelerate lactate dehydrogenase reaction and shorten post-exercise recovery time.
🌐
4. Application Scenario Expansion
Widely used in sports nutrition supplements, postoperative recovery formulas and anti-aging health products. Clinical studies have shown that it has the potential to assist in improving metabolic syndrome and neurodegenerative diseases. Its phosphorylated structure makes it suitable for oral preparations and functional food development, becoming a targeted nutritional solution for threonine upgrade replacement.
Frequently Asked Questions (FAQ)
What is O-Phospho-L-threonine (CAS 1114-81-4)?
O-Phospho-L-threonine is a phosphorylated derivative of the amino acid threonine, with the molecular formula C₄H₁₀NO₆P. The addition of a phosphate group significantly enhances its biological activity, water solubility, and functional diversity compared to regular threonine.
How does O-Phospho-L-threonine support immune health?
It enhances T/B cell receptor signal transduction to boost lymphocyte activation, increases antibody secretion and diversity, and inhibits the NF-κB inflammatory pathway to reduce the secretion of pro-inflammatory cytokines such as TNF-α and IL-6.
What are the benefits of O-Phospho-L-threonine for sports nutrition?
It improves glycolysis efficiency in muscle cells to prolong exercise endurance, accelerates the lactate dehydrogenase reaction to speed up lactic acid clearance, reduces creatine kinase levels post-exercise, and helps relieve delayed onset muscle soreness (DOMS).
How does phosphorylation improve the stability of L-threonine?
Phosphorylation modification increases the molecular polarity of threonine, which significantly improves both its water solubility and thermal stability. This makes it more suitable for use in a wide variety of formulation types, including oral supplements and functional foods, across diverse processing conditions.
What neuroprotective effects does O-Phospho-L-threonine offer?
It upregulates glutathione peroxidase activity to neutralize free radicals and reduce oxidative stress. It also promotes the synthesis of brain-derived neurotrophic factor (BDNF), which supports synaptic plasticity and helps maintain the stability of neuronal networks.
In what types of products is O-Phospho-L-threonine commonly used?
It is widely applied in sports nutrition supplements, postoperative recovery formulas, anti-aging health products, oral preparations, and functional foods. It also shows clinical potential in assisting the management of metabolic syndrome and neurodegenerative conditions, making it a versatile ingredient for targeted nutritional applications.