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O-Phospho-L-threonine - Quality Threonine Suppliers & Factory in China【CAS: 37210-61-0】
C4H10NO6P
Description
L-O-phospho-threonine (O-Phospho-L-threonine, CAS No. 1114-81-4) is a phosphorylated derivative of threonine. By introducing a phosphate group, its biological activity and functional diversity are significantly enhanced, showing unique value in the field of nutrition and health care.
Technical Advantages Analysis
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Signal Transduction Enhancement As a biological signal molecule, the phosphate group activates the protein kinase cascade reaction, regulates cell metabolism, differentiation and stress adaptation. Its negative charge characteristics enhance the affinity with the target protein and improve the efficiency of signal transduction.
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Metabolic Regulation Upgrade Promote glycogen synthase phosphorylation and accelerate glycogen storage; synchronously activate the pyruvate dehydrogenase complex and optimize the efficiency of mitochondrial ATP generation.
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Stability Improvement Phosphorylation modification enhances molecular polarity, improves water solubility and thermal stability, and broadens the application scenarios of formulation development.
Core Role of Nutrition and Health Care
1
Cell Repair & Regeneration
- Wound Healing: Activate fibroblast proliferation, promote orderly deposition of collagen, and shorten the wound healing cycle.
- Muscle Recovery: Reduce the level of creatine kinase after exercise and relieve delayed muscle soreness.
2
Immune Empowerment
- Lymphocyte Activation: Enhance T/B cell receptor signal transduction, increase antibody secretion and diversity.
- Anti-inflammatory Regulation: Inhibit NF-κB pathway, reduce pro-inflammatory factors TNF-α, IL-6 secretion.
- Neuroprotection / Antioxidant Barrier: Upregulate glutathione peroxidase activity and scavenge free radicals.
- Synaptic Plasticity: Promote BDNF synthesis and maintain neuronal network stability.
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Sports Nutrition Support
- Energy Optimization: Improve muscle cell glycolysis efficiency and prolong exercise endurance.
- Lactic Acid Metabolism: Accelerate lactate dehydrogenase reaction and shorten post-exercise recovery time.
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Application Scenario Expansion
- Widely used in sports nutrition supplements, postoperative recovery formulas and anti-aging health products.
- Clinical studies show potential to assist in improving metabolic syndrome and neurodegenerative diseases.
- Suitable for oral preparations and functional food development as a targeted nutritional solution.
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Its phosphorylated structure makes O-Phospho-L-threonine a targeted nutritional solution for threonine upgrade replacement — bridging advanced biochemistry with practical formulation development across sports nutrition, clinical recovery, and functional food sectors.
Frequently Asked Questions (FAQ)
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What is O-Phospho-L-threonine (CAS No. 1114-81-4)?
O-Phospho-L-threonine is a phosphorylated derivative of the amino acid threonine, with the molecular formula C₄H₁₀NO₆P. A phosphate group is covalently attached to the hydroxyl side chain of L-threonine, significantly enhancing its biological activity, water solubility, and functional versatility in nutritional and pharmaceutical applications.
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How does O-Phospho-L-threonine support signal transduction in the body?
The phosphate group in O-Phospho-L-threonine acts as a biological signal molecule that activates protein kinase cascade reactions. Its negatively charged structure enhances affinity with target proteins, thereby improving signal transduction efficiency and regulating key cellular processes including metabolism, differentiation, and stress adaptation.
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What are the key benefits of O-Phospho-L-threonine for sports nutrition?
For athletes and active individuals, O-Phospho-L-threonine offers multiple benefits: it improves muscle cell glycolysis efficiency to extend exercise endurance, accelerates lactate dehydrogenase reactions to shorten post-exercise recovery time, and reduces creatine kinase levels after exercise to relieve delayed muscle soreness.
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Can O-Phospho-L-threonine support immune function?
Yes. O-Phospho-L-threonine enhances T/B cell receptor signal transduction to increase antibody secretion and diversity. It also inhibits the NF-κB pathway, reducing the secretion of pro-inflammatory factors such as TNF-α and IL-6, thereby contributing to a balanced and regulated immune response.
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What makes O-Phospho-L-threonine suitable for formulation development?
Phosphorylation modification enhances the molecular polarity of threonine, resulting in improved water solubility and thermal stability. These properties make O-Phospho-L-threonine highly compatible with oral preparations, functional food formulations, sports supplements, postoperative recovery products, and anti-aging health care solutions.
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Are there potential clinical applications for O-Phospho-L-threonine?
Clinical studies indicate that O-Phospho-L-threonine has the potential to assist in improving metabolic syndrome and neurodegenerative diseases. Its neuroprotective properties — including upregulation of glutathione peroxidase activity and promotion of brain-derived neurotrophic factor (BDNF) synthesis — position it as a promising ingredient in targeted therapeutic nutrition research.