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O-Phospho-L-threonine - High-Quality Threoninium Dihydrogen Phosphate from China Suppliers & Factory
C4H10NO6P
Molecular Formula · CAS No. 1114-81-4
📋 Description
L-O-phospho-threonine (O-Phospho-L-threonine, CAS No. 1114-81-4) is a phosphorylated derivative of threonine. By introducing a phosphate group, its biological activity and functional diversity are significantly enhanced, showing unique value in the field of nutrition and health care.
⚗️ Technical Advantages Analysis
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Signal Transduction Enhancement As a biological signal molecule, the phosphate group activates the protein kinase cascade reaction, regulates cell metabolism, differentiation and stress adaptation. Its negative charge characteristics enhance the affinity with the target protein and improve the efficiency of signal transduction.
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Metabolic Regulation Upgrade Promote glycogen synthase phosphorylation and accelerate glycogen storage; synchronously activate the pyruvate dehydrogenase complex and optimize the efficiency of mitochondrial ATP generation.
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Stability Improvement Phosphorylation modification enhances molecular polarity, improves water solubility and thermal stability, and broadens the application scenarios of formulation development.
💊 Core Role of Nutrition and Health Care
🩹 1. Cell Repair & Regeneration
- Wound Healing: Activate fibroblast proliferation, promote orderly deposition of collagen, and shorten the wound healing cycle.
- Muscle Recovery: Reduce the level of creatine kinase after exercise and relieve delayed muscle soreness.
🧬 2. Immune Empowerment
- Lymphocyte Activation: Enhance T/B cell receptor signal transduction, increase antibody secretion and diversity.
- Anti-inflammatory Regulation: Inhibit NF-κB pathway, reduce pro-inflammatory factors TNF-α, IL-6 secretion.
- Neuroprotection — Antioxidant Barrier: Upregulate glutathione peroxidase activity and scavenge free radicals.
- Synaptic Plasticity: Promote BDNF synthesis and maintain neuronal network stability.
🏋️ 3. Sports Nutrition Support
- Energy Optimization: Improve muscle cell glycolysis efficiency and prolong exercise endurance.
- Lactic Acid Metabolism: Accelerate lactate dehydrogenase reaction and shorten post-exercise recovery time.
🌐 4. Application Scenario Expansion
- Sports nutrition supplements
- Postoperative recovery formulas
- Anti-aging health products
- Oral preparations & functional food development
- Potential to assist in metabolic syndrome & neurodegenerative disease management
📌 Clinical Insight
Clinical studies have shown that L-O-phospho-threonine has the potential to assist in improving metabolic syndrome and neurodegenerative diseases. Its phosphorylated structure makes it suitable for oral preparations and functional food development, becoming a targeted nutritional solution for threonine upgrade replacement.
❓ Frequently Asked Questions
Q What is L-O-phospho-threonine (CAS No. 1114-81-4)?
L-O-phospho-threonine, also known as O-Phospho-L-threonine, is a phosphorylated derivative of the amino acid threonine. With the molecular formula C₄H₁₀NO₆P, it features an added phosphate group that significantly enhances its biological activity and functional versatility compared to standard threonine.
Q How does L-O-phospho-threonine support immune function?
It enhances T/B cell receptor signal transduction to increase antibody secretion and diversity. Additionally, it inhibits the NF-κB pathway to reduce the secretion of pro-inflammatory cytokines such as TNF-α and IL-6, providing a measurable anti-inflammatory effect.
Q What are the sports nutrition benefits of L-O-phospho-threonine?
For athletes and active individuals, L-O-phospho-threonine improves muscle cell glycolysis efficiency to extend exercise endurance, accelerates lactate dehydrogenase reactions to shorten post-exercise recovery time, and reduces creatine kinase levels to relieve delayed-onset muscle soreness.
Q In what types of products can L-O-phospho-threonine be used?
Due to its enhanced water solubility and thermal stability from phosphorylation, it is widely applicable in sports nutrition supplements, postoperative recovery formulas, anti-aging health products, oral pharmaceutical preparations, and functional food development.
Q How does phosphorylation improve the stability of threonine?
The introduction of the phosphate group enhances molecular polarity, which in turn improves water solubility and thermal stability. This makes L-O-phospho-threonine more robust across a wider range of formulation development scenarios compared to unmodified threonine.
Q What role does L-O-phospho-threonine play in neuroprotection?
It upregulates glutathione peroxidase activity to scavenge harmful free radicals, providing an antioxidant barrier. It also promotes the synthesis of brain-derived neurotrophic factor (BDNF) and supports synaptic plasticity, helping maintain neuronal network stability and showing potential in addressing neurodegenerative conditions.