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O-Phospho-L-threonine - High-Quality Phosphothreonine from China Suppliers & Factory
C4H10NO6P
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Description
L-O-phospho-threonine (O-Phospho-L-threonine, CAS No. 1114-81-4) is a phosphorylated derivative of threonine. By introducing a phosphate group, its biological activity and functional diversity are significantly enhanced, showing unique value in the field of nutrition and health care.
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Technical Advantages Analysis
Signal Transduction Enhancement
As a biological signal molecule, the phosphate group activates the protein kinase cascade reaction, regulates cell metabolism, differentiation and stress adaptation. Its negative charge characteristics enhance the affinity with the target protein and improve the efficiency of signal transduction.
Metabolic Regulation Upgrade
Promote glycogen synthase phosphorylation and accelerate glycogen storage; synchronously activate the pyruvate dehydrogenase complex and optimize the efficiency of mitochondrial ATP generation.
Stability Improvement
Phosphorylation modification enhances molecular polarity, improves water solubility and thermal stability, and broadens the application scenarios of formulation development.
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Core Role of Nutrition and Health Care
1Cell Repair and Regeneration
Wound Healing: Activate fibroblast proliferation, promote orderly deposition of collagen, and shorten the wound healing cycle.
Muscle Recovery: Reduce the level of creatine kinase after exercise and relieve delayed muscle soreness.
2Immune Empowerment
Lymphocyte Activation: Enhance T/B cell receptor signal transduction, increase antibody secretion and diversity.
Anti-Inflammatory Regulation: Inhibit NF-κB pathway, reduce pro-inflammatory factors TNF-α, IL-6 secretion.
Neuroprotection — Antioxidant Barrier: Upregulate glutathione peroxidase activity and scavenge free radicals.
Synaptic Plasticity: Promote brain-derived neurotrophic factor (BDNF) synthesis and maintain neuronal network stability.
3Sports Nutrition Support
Energy Optimization: Improve muscle cell glycolysis efficiency and prolong exercise endurance.
Lactic Acid Metabolism: Accelerate lactate dehydrogenase reaction and shorten post-exercise recovery time.
4Application Scenario Expansion
Widely used in sports nutrition supplements, postoperative recovery formulas and anti-aging health products. Clinical studies have shown that it has the potential to assist in improving metabolic syndrome and neurodegenerative diseases. Its phosphorylated structure makes it suitable for oral preparations and functional food development, becoming a targeted nutritional solution for threonine upgrade replacement.
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Frequently Asked Questions
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What is L-O-phospho-threonine (O-Phospho-L-threonine)?
L-O-phospho-threonine (CAS No. 1114-81-4) is a phosphorylated derivative of the amino acid threonine. The introduction of a phosphate group significantly enhances its biological activity and functional diversity, making it valuable in nutrition, health care, and pharmaceutical applications.
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How does O-Phospho-L-threonine enhance signal transduction in cells?
As a biological signal molecule, its phosphate group activates the protein kinase cascade reaction, regulating cell metabolism, differentiation, and stress adaptation. The negative charge of the phosphate group improves its binding affinity with target proteins, thereby increasing signal transduction efficiency.
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What are the benefits of O-Phospho-L-threonine for sports nutrition?
It improves muscle cell glycolysis efficiency to prolong exercise endurance, reduces creatine kinase levels post-exercise to relieve delayed muscle soreness, and accelerates the lactate dehydrogenase reaction to shorten post-exercise recovery time.
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Can O-Phospho-L-threonine support immune system function?
Yes. It enhances T/B cell receptor signal transduction to increase antibody secretion and diversity. It also inhibits the NF-κB pathway to reduce the secretion of pro-inflammatory factors such as TNF-α and IL-6, providing both immune activation and anti-inflammatory regulation.
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What makes O-Phospho-L-threonine stable and suitable for formulation development?
Phosphorylation modification enhances the molecular polarity of threonine, which in turn improves its water solubility and thermal stability. These properties broaden its applicability in various formulation scenarios, including oral preparations and functional food products.
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What are the main application areas of O-Phospho-L-threonine?
O-Phospho-L-threonine is widely applied in sports nutrition supplements, postoperative recovery formulas, and anti-aging health products. Clinical studies indicate its potential in assisting with metabolic syndrome and neurodegenerative disease management, making it a targeted nutritional solution for threonine upgrade replacement.