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O-Phospho-L-serine Suppliers in China | Quality L-O-phosphoserine from Trusted Factory
C3H8NO6P
Description
L-O-phosphoserine (O-Phospho-L-serine, CAS No. 407-41-0) is a phosphorylated derivative of serine. By introducing a phosphate group, its biological activity and functional diversity are significantly enhanced, showing unique value in the field of nutrition and health care. The following is a detailed introduction:
Technical Advantage Analysis
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Neural Signal Regulation
As an agonist of the third group of metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, mGluR8), it antagonizes mGluR1 and mGluR2 at the same time, accurately regulates neurotransmitter transmission and neuronal excitability, and improves cognitive function.
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Metabolic Enhancement
Promotes phosphatidylserine synthesis and maintains cell membrane integrity; accelerates amino acid metabolism, supports protein synthesis, and optimizes energy utilization.
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Stability Improvement
Phosphorylation modification enhances molecular polarity, improves water solubility and thermal stability, and broadens the application scenarios of formulation development.
Core Role of Nutrition and Health Care
1
Neuroprotection and Cognitive Enhancement
Antioxidant Barrier: Upregulates glutathione peroxidase activity, scavenges free radicals, and reduces neuronal damage.
Synaptic Plasticity: Promotes the synthesis of brain-derived neurotrophic factor (BDNF) and enhances learning and memory abilities.
Emotional Regulation: Participates in the synthesis of serotonin and relieves anxiety and depression.
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Immune Empowerment
Lymphocyte Activation: Enhances T/B cell receptor signal transduction, increases antibody secretion and diversity.
Anti-inflammatory Regulation: Inhibits the NF-κB pathway, reduces the secretion of pro-inflammatory factors TNF-α and IL-6, and relieves chronic inflammation.
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Sleep Optimization
Circadian Rhythm Regulation: Promotes melatonin secretion, improves sleep difficulties and night awakening problems.
Improved Sleep Quality: Extends the deep sleep stage and enhances sleep recovery effects.
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Cardiovascular Support
Blood Pressure Regulation: Assists in controlling the conduction of cardiac and vascular nerve impulses and stabilizes blood pressure levels.
Endothelial Protection: Enhances vascular antioxidant capacity and prevents atherosclerosis.
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Application Scenario Expansion
Widely used in anti-fatigue dietary supplements, cognitive enhancement formulas and cardiovascular health products. Clinical studies have shown that it has the potential to assist in improving Alzheimer's disease and Parkinson's disease. Its phosphorylated structure makes it suitable for the development of oral preparations and functional foods, making it a targeted nutritional solution for serine upgrade replacement.
Frequently Asked Questions (FAQ)
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What is L-O-Phosphoserine (O-Phospho-L-serine) and what is its CAS number?
L-O-Phosphoserine (also known as O-Phospho-L-serine) is a phosphorylated derivative of the amino acid serine, with the molecular formula C₃H₈NO₆P. Its CAS number is 407-41-0. The addition of a phosphate group significantly enhances its biological activity and functional diversity compared to standard serine.
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How does L-O-Phosphoserine support brain health and cognitive function?
L-O-Phosphoserine acts as an agonist of Group III metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, mGluR8), precisely regulating neurotransmitter transmission. It also promotes BDNF synthesis to strengthen learning and memory, upregulates antioxidant enzymes to protect neurons, and participates in serotonin synthesis to support emotional well-being.
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What are the immune-boosting properties of L-O-Phosphoserine?
L-O-Phosphoserine enhances T and B cell receptor signal transduction, boosting antibody secretion and diversity. It also inhibits the NF-κB inflammatory pathway and reduces the secretion of pro-inflammatory cytokines such as TNF-α and IL-6, helping to manage and relieve chronic inflammation.
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Can L-O-Phosphoserine help improve sleep quality?
Yes. L-O-Phosphoserine promotes melatonin secretion to regulate circadian rhythms, which helps address sleep onset difficulties and nighttime awakening. It also works to extend the deep sleep stage, enhancing the overall restorative quality of sleep.
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What makes the phosphorylated form of serine more stable and versatile for formulation?
The phosphorylation modification of serine increases its molecular polarity, which in turn improves both its water solubility and thermal stability. These enhanced properties broaden its applicability in formulation development, making it suitable for oral preparations, functional foods, and a wide range of dietary supplement formats.
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What health conditions or products is L-O-Phosphoserine commonly used for?
L-O-Phosphoserine is widely applied in anti-fatigue dietary supplements, cognitive enhancement formulas, and cardiovascular health products. Clinical research also suggests it has potential to assist in managing Alzheimer's disease and Parkinson's disease, positioning it as a high-value targeted nutritional ingredient for advanced serine supplementation.