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O-Phospho-L-serine Suppliers in China - High-Quality Dexfosfoserine from Trusted Factory
C3H8NO6P
🔬 Description
L-O-phosphoserine (O-Phospho-L-serine, CAS No. 407-41-0) is a phosphorylated derivative of serine. By introducing a phosphate group, its biological activity and functional diversity are significantly enhanced, showing unique value in the field of nutrition and health care. The following is a detailed introduction:
⚙️ Technical Advantage Analysis
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Neural Signal Regulation
As an agonist of the third group of metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, mGluR8), it antagonizes mGluR1 and mGluR2, accurately regulates neurotransmitter transmission and neuronal excitability, and improves cognitive function.
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Metabolic Enhancement
Promotes phosphatidylserine synthesis and maintains cell membrane integrity; accelerates amino acid metabolism, supports protein synthesis, and optimizes energy utilization.
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Stability Improvement
Phosphorylation modification enhances molecular polarity, improves water solubility and thermal stability, and broadens the application scenarios of formulation development.
💊 Core Role of Nutrition and Health Care
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1 Neuroprotection and Cognitive EnhancementAntioxidant Barrier: Upregulates glutathione peroxidase activity, scavenges free radicals, and reduces neuronal damage.Synaptic Plasticity: Promotes the synthesis of brain-derived neurotrophic factor (BDNF) and enhances learning and memory abilities.Emotional Regulation: Participates in the synthesis of serotonin and relieves anxiety and depression.
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2 Immune EmpowermentLymphocyte Activation: Enhances T/B cell receptor signal transduction, increases antibody secretion and diversity.Anti-inflammatory Regulation: Inhibits the NF-κB pathway, reduces the secretion of pro-inflammatory factors TNF-α and IL-6, and relieves chronic inflammation.
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3 Sleep OptimizationCircadian Rhythm Regulation: Promotes melatonin secretion, improves sleep difficulties and night awakening problems.Improved Sleep Quality: Extends the deep sleep stage and enhances sleep recovery effects.
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4 Cardiovascular SupportBlood Pressure Regulation: Assists in controlling the conduction of cardiac and vascular nerve impulses and stabilizes blood pressure levels.Endothelial Protection: Enhances vascular antioxidant capacity and prevents atherosclerosis.
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5 Application Scenario ExpansionWidely used in anti-fatigue dietary supplements, cognitive enhancement formulas and cardiovascular health products. Clinical studies have shown that it has the potential to assist in improving Alzheimer's disease and Parkinson's disease. Its phosphorylated structure makes it suitable for the development of oral preparations and functional foods, making it a targeted nutritional solution for serine upgrade replacement.
❓ Frequently Asked Questions (FAQ)
Q
What is L-O-Phosphoserine (O-Phospho-L-Serine) and what is its CAS number?
L-O-Phosphoserine (also known as O-Phospho-L-Serine) is a phosphorylated derivative of the amino acid serine with the molecular formula C₃H₈NO₆P. Its CAS number is 407-41-0. The addition of a phosphate group significantly enhances its biological activity and functional versatility compared to standard serine.
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How does L-O-Phosphoserine support brain and cognitive health?
L-O-Phosphoserine acts as an agonist of metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, mGluR8), helping regulate neurotransmitter transmission and neuronal excitability. It also promotes BDNF synthesis to enhance learning and memory, upregulates antioxidant enzymes to protect neurons, and participates in serotonin synthesis to support emotional balance.
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Can L-O-Phosphoserine help improve sleep quality?
Yes. L-O-Phosphoserine is involved in circadian rhythm regulation by promoting melatonin secretion, which can help address sleep difficulties and nighttime awakenings. Additionally, it has been shown to extend the deep sleep stage, thereby enhancing overall sleep recovery and quality.
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What are the immune-supporting properties of L-O-Phosphoserine?
L-O-Phosphoserine enhances the immune system by activating T and B lymphocyte receptor signaling, which increases antibody secretion and diversity. It also inhibits the NF-κB inflammatory pathway, reducing the secretion of pro-inflammatory cytokines TNF-α and IL-6, thus offering effective anti-inflammatory regulation and relief from chronic inflammation.
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What makes L-O-Phosphoserine more stable and suitable for formulation development?
The phosphorylation modification of serine enhances molecular polarity, which significantly improves both water solubility and thermal stability. These properties make L-O-Phosphoserine more suitable for a wider range of formulation applications, including oral preparations and functional foods, compared to non-phosphorylated serine.
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In what types of health products is L-O-Phosphoserine commonly used?
L-O-Phosphoserine is widely applied in anti-fatigue dietary supplements, cognitive enhancement formulas, sleep support products, and cardiovascular health solutions. Clinical research also suggests potential applications in assisting with conditions such as Alzheimer's disease and Parkinson's disease, making it a versatile and targeted nutritional ingredient.