Amino acids
0102030405
O-Phospho-DL-serine / Serophen / DL-O-phosphoserine / DL-O-phosphoserinate
C3H8NO6P
The core difference from L-O-phosphoserine
Molecular configuration: DL type contains two enantiomers, D/L, while L type has only a single configuration, which may affect receptor binding selectivity.
Target of action: L type mainly acts on the nervous system (such as mGluR regulation), while DL type may extend to metabolism and immune-related pathways due to its configuration diversity.
Detailed explanation of nutritional health effects
1.Metabolic regulation
Glycolipid balance: activates glycogen synthase and accelerates liver glycogen reserves; optimizes fatty acid β-oxidation and reduces lipid accumulation.
Protein synthesis: as a serine donor, participates in purine and pyrimidine synthesis, supports muscle repair and immune protein production.
2.Immune empowerment
Lymphocyte activation: enhances NK cell toxicity and improves neutrophil phagocytosis efficiency.
Anti-inflammatory regulation: inhibits NLRP3 inflammasome activation and reduces IL-1β and IL-18 secretion.
Cardiovascular support
Blood pressure regulation: antagonizes angiotensin II receptors and dilates peripheral blood vessels.
Endothelial protection: upregulate eNOS expression, promote nitric oxide production, and improve blood flow-mediated vasodilation.
3.Antioxidant defense
Free radical scavenging: chelate iron ions, inhibit Fenton reaction, and reduce hydroxyl radical generation.
Mitochondrial protection: maintain mitochondrial membrane potential and reduce cytochrome C release.
4.Application scenario expansion
Functional food: used in nutritional intervention formulas for metabolic syndrome to regulate blood sugar and blood lipids.
Clinical nutrition: adjuvant treatment of autoimmune diseases (such as rheumatoid arthritis) and postoperative infections.
Sports nutrition: optimize energy metabolism, improve endurance performance, and accelerate muscle repair.
Summary of technical advantages
Multi-target synergy: D/L configuration synergy, covering multiple systems of nerve-metabolism-immunity.
Stability optimization: phosphorylation modification enhances polarity and improves oral bioavailability.
Safety: as an endogenous metabolite, it is well tolerated and suitable for long-term supplementation.
DL-O-phosphoserine shows unique advantages in the fields of metabolic regulation, immune support and cardiovascular health through multi-mechanism synergy, becoming an upgraded alternative to serine nutrients.