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China Supplier of O-Phospho-L-Serine / Dexfosfoserine / L-O-Phosphoserinate from Quality Factory
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China Supplier of O-Phospho-L-Serine / Dexfosfoserine / L-O-Phosphoserinate from Quality Factory

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  • CAS:  407-41-0

C3H8NO6P
O-Phospho-L-serine Chemical Structure
Description
L-O-phosphoserine (O-Phospho-L-serine, CAS No. 407-41-0) is a phosphorylated derivative of serine. By introducing a phosphate group, its biological activity and functional diversity are significantly enhanced, showing unique value in the field of nutrition and health care.
Technical Advantage Analysis
Neural Signal Regulation
As an agonist of the third group of metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, mGluR8), it antagonizes mGluR1 and mGluR2 at the same time, accurately regulates neurotransmitter transmission and neuronal excitability, and improves cognitive function.
Metabolic Enhancement
Promotes phosphatidylserine synthesis and maintains cell membrane integrity; accelerates amino acid metabolism, supports protein synthesis, and optimizes energy utilization.
Stability Improvement
Phosphorylation modification enhances molecular polarity, improves water solubility and thermal stability, and broadens the application scenarios of formulation development.
Core Role of Nutrition and Health Care
1. Neuroprotection and Cognitive Enhancement
  • Antioxidant Barrier: Upregulates glutathione peroxidase activity, scavenges free radicals, and reduces neuronal damage.
  • Synaptic plasticity: Promotes the synthesis of brain-derived neurotrophic factor (BDNF) and enhances learning and memory abilities.
  • Emotional regulation: Participates in the synthesis of serotonin and relieves anxiety and depression.
2. Immune Empowerment
  • Lymphocyte activation: Enhances T/B cell receptor signal transduction, increases antibody secretion and diversity.
  • Anti-inflammatory regulation: Inhibits the NF-κB pathway, reduces the secretion of pro-inflammatory factors TNF-α and IL-6, and relieves chronic inflammation.
3. Sleep Optimization
  • Circadian rhythm regulation: Promotes melatonin secretion, improves sleep difficulties and night awakening problems.
  • Improved sleep quality: Extends the deep sleep stage and enhances sleep recovery effects.
4. Cardiovascular Support
  • Blood pressure regulation: Assists in controlling the conduction of cardiac and vascular nerve impulses and stabilizes blood pressure levels.
  • Endothelial protection: Enhances vascular antioxidant capacity and prevents atherosclerosis.
5. Application Scenario Expansion
Widely used in anti-fatigue dietary supplements, cognitive enhancement formulas and cardiovascular health products. Clinical studies have shown that it has the potential to assist in improving Alzheimer's disease and Parkinson's disease. Its phosphorylated structure makes it suitable for the development of oral preparations and functional foods, making it a targeted nutritional solution for serine upgrade replacement.
Frequently Asked Questions (FAQ)

Q1: What is L-O-phosphoserine?

L-O-phosphoserine (O-Phospho-L-serine, CAS No. 407-41-0) is a phosphorylated derivative of serine. The introduction of a phosphate group significantly enhances its biological activity and functional diversity.

Q2: How does L-O-phosphoserine benefit cognitive function?

It regulates neurotransmitter transmission and neuronal excitability, scavenges free radicals to reduce neuronal damage, and promotes the synthesis of BDNF, which enhances learning and memory abilities.

Q3: Can it help improve sleep quality?

Yes, it helps regulate the circadian rhythm by promoting melatonin secretion, which improves sleep difficulties, extends the deep sleep stage, and enhances overall sleep recovery.

Q4: What role does it play in the immune system?

It enhances T and B cell receptor signal transduction to increase antibody secretion and diversity. Additionally, it relieves chronic inflammation by inhibiting the NF-κB pathway and reducing pro-inflammatory factors.

Q5: Is L-O-phosphoserine beneficial for cardiovascular health?

Absolutely. It assists in controlling the conduction of cardiac and vascular nerve impulses to stabilize blood pressure levels and enhances vascular antioxidant capacity to prevent atherosclerosis.

Q6: What are the main application scenarios for this ingredient?

It is widely used in anti-fatigue dietary supplements, cognitive enhancement formulas, and cardiovascular health products. Its excellent water solubility and thermal stability make it ideal for oral preparations and functional foods.