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CAS: 1114-81-4

Product Detail

C₄H₁₀NO₆P

L-O-phospho-threonine Chemical Formula Structure

Description

L-O-phospho-threonine (O-Phospho-L-threonine, CAS No. 1114-81-4) is a phosphorylated derivative of threonine. By introducing a phosphate group, its biological activity and functional diversity are significantly enhanced, showing unique value in the field of nutrition and health care.

Technical Advantages Analysis

Signal Transduction

As a biological signal molecule, the phosphate group activates the protein kinase cascade reaction, regulates cell metabolism, differentiation and stress adaptation. Its negative charge characteristics enhance the affinity with the target protein and improve the efficiency of signal transduction.

Metabolic Regulation

Promote glycogen synthase phosphorylation and accelerate glycogen storage; synchronously activate the pyruvate dehydrogenase complex and optimize the efficiency of mitochondrial ATP generation.

Stability Improvement

Phosphorylation modification enhances molecular polarity, improves water solubility and thermal stability, and broadens the application scenarios of formulation development.

Core Role of Nutrition and Health Care

1 Cell Repair & Regeneration

Wound healing:

Activate fibroblast proliferation, promote orderly deposition of collagen, and shorten the wound healing cycle.

Muscle recovery:

Reduce the level of creatine kinase after exercise and relieve delayed muscle soreness.

2 Immune Empowerment

Lymphocyte activation:

Enhance T/B cell receptor signal transduction, increase antibody secretion and diversity.

Anti-inflammatory regulation:

Inhibit NF-κB pathway, reduce pro-inflammatory factors TNF-α, IL-6 secretion.

3 Neuroprotection

Antioxidant barrier:

Upregulate glutathione peroxidase activity and scavenge free radicals.

Synaptic plasticity:

Promote brain-derived neurotrophic factor (BDNF) synthesis and maintain neuronal network stability.

4 Sports Nutrition Support

Energy optimization:

Improve muscle cell glycolysis efficiency and prolong exercise endurance.

Lactic acid metabolism:

Accelerate lactate dehydrogenase reaction and shorten post-exercise recovery time.

Application Scenario Expansion

Widely used in sports nutrition supplements, postoperative recovery formulas and anti-aging health products. Clinical studies have shown that it has the potential to assist in improving metabolic syndrome and neurodegenerative diseases. Its phosphorylated structure makes it suitable for oral preparations and functional food development, becoming a targeted nutritional solution for threonine upgrade replacement.

Frequently Asked Questions

What is L-O-phospho-threonine?

L-O-phospho-threonine (O-Phospho-L-threonine, CAS No. 1114-81-4) is a phosphorylated derivative of threonine. The introduction of the phosphate group significantly enhances its biological activity and functional diversity, offering unique value in the field of nutrition and health care.

What are the technical advantages of L-O-phospho-threonine?

It provides three main advantages: enhanced signal transduction via protein kinase cascade activation, upgraded metabolic regulation that optimizes mitochondrial ATP generation and glycogen storage, and improved stability through phosphorylation which enhances water solubility and thermal stability.

How does L-O-phospho-threonine support cell repair and muscle recovery?

For cell repair, it activates fibroblast proliferation to promote orderly collagen deposition and shorten wound healing times. For muscle recovery, it helps reduce creatine kinase levels after exercise, thereby relieving delayed muscle soreness.

How does L-O-phospho-threonine benefit the immune system and brain health?

It empowers immunity by enhancing T/B cell receptor signal transduction, increasing antibody secretion, and reducing pro-inflammatory factors (TNF-α, IL-6) via NF-κB pathway inhibition. It provides neuroprotection by upregulating glutathione peroxidase activity and promoting BDNF synthesis to maintain neuronal network stability.

In what applications is L-O-phospho-threonine commonly used?

It is widely used in sports nutrition supplements (improving glycolysis efficiency and accelerating lactate metabolism), postoperative recovery formulas, and anti-aging health products. Its high solubility and stability make it perfect for oral preparations and functional food development.