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Bisbentiamine Suppliers in China - Premium Thiamine Disulfide from Reliable Factory
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Bisbentiamine Suppliers in China - Premium Thiamine Disulfide from Reliable Factory

Bisbentiamine (CAS No. 2667-89-is an advanced derivative of vitamin B1 (thiamine), known as dibenzoyl disulfide thiamine. With its molecular formula C₃₈H₄₂N₈O₆S₂ and a molecular weight of 770.92, Bisbentiamine is a vital compound for various health applications. As a leading supplier and factory in China, we ensure the highest quality standards for this unique product, catering to the needs of manufacturers and researchers globally. Explore our Bisbentiamine offerings and benefit from our expertise as one of the top suppliers in the market

    Basic Information and Chemical Properties

    Bisbentiamine (CAS No. 2667-89-2) is a derivative of vitamin B1 (thiamine), with the chemical name of dibenzoyl disulfide thiamine. Its structural feature is that two benzoyl groups are connected by a disulfide bond, which gives it unique fat solubility and stability. It needs to be stored away from light and moisture at room temperature.

    Molecular Formula
    C₃₈H₄₂N₈O₆S₂
    Molecular Weight
    770.92
    CAS No.
    2667-89-2
    Density
    1.331 g/cm³
    Melting Point
    140–145 °C
    Boiling Point
    987.4 °C (predicted)
    Functional Mechanism and Nutritional Health Effects

    As a derivative of vitamin B1, bisbenzylthiamine has multiple potentials in the field of nutritional supplementation by optimizing bioavailability:

    • 1
      Enhanced Bioavailability

      Compared with water-soluble thiamine, its fat-soluble structure is easier to pass through the cell membrane, improving absorption efficiency, thereby increasing the level of active coenzymes such as thiamine pyrophosphate (TPP) in the body, supporting energy metabolism and nervous system function.

    • 2
      Regulating Sugar Metabolism and Anti-Oxidation

      By activating transketolase, it promotes the normalization of glucose metabolism and reduces the accumulation of advanced glycation end products (AGEs), thereby combating oxidative damage and diabetic complications (such as neuropathy and retinopathy) caused by hyperglycemia.

    • 3
      Synergistic Effect

      Some dietary supplements combine it with other B vitamins (such as thiamine sulfozincate) to optimize metabolic pathways and enhance anti-fatigue and neuroprotective effects through the synergistic effect of coenzyme forms.

    Application Scenarios and Product Examples

    The application of bisbenzamide in dietary supplements is mainly concentrated in the following directions:

    • 1
      Diabetes and Metabolic Health

      For people with high blood sugar, it protects blood vessels and nerve tissues by inhibiting the formation of AGEs, and is often used to prevent complications such as diabetic neuropathy.

    • 2
      Energy Metabolism and Anti-Fatigue

      As a coenzyme, it participates in the tricarboxylic acid cycle and promotes the conversion of carbohydrates into energy. It is suitable for people with high physical exertion or easy fatigue.

    • 3
      Nervous System Support

      Improve vitamin B1 deficiency caused by alcoholism or malnutrition, and maintain nerve conduction function.

    Bisbentiamine has become a popular ingredient in the field of nutritional supplements due to its high bioavailability and multiple metabolic regulation functions. However, its application still needs to be combined with individual needs and scientifically supplemented on the basis of a balanced diet. In the future, with the advancement of synthetic biology technology and the deepening of clinical research, the potential of this ingredient in the field of chronic disease prevention and precision nutrition will be further released.
    Frequently Asked Questions (FAQ)
    Q What is Bisbentiamine and how does it differ from regular Vitamin B1?
    Bisbentiamine (CAS No. 2667-89-2) is a fat-soluble derivative of vitamin B1 (thiamine). Unlike regular water-soluble thiamine, its structure — featuring two benzoyl groups connected by a disulfide bond — allows it to pass through cell membranes more efficiently, resulting in significantly higher bioavailability and more effective conversion to active coenzyme forms in the body.
    Q How does Bisbentiamine support blood sugar management?
    Bisbentiamine activates transketolase, a key enzyme in glucose metabolism, which helps normalize glucose processing and reduces the buildup of advanced glycation end products (AGEs). This mechanism helps protect blood vessels and nerve tissues from damage associated with high blood sugar levels, making it beneficial for people managing diabetes or metabolic health concerns.
    Q Can Bisbentiamine be used to combat fatigue and improve energy levels?
    Yes. As a coenzyme involved in the tricarboxylic acid (TCA) cycle, Bisbentiamine plays a direct role in converting carbohydrates into usable energy. It is particularly suitable for individuals with high physical demands or those who experience chronic fatigue, as it supports more efficient energy metabolism at the cellular level.
    Q Is Bisbentiamine safe to take with other B vitamins?
    Bisbentiamine is commonly combined with other B vitamins, such as thiamine sulfozincate, in dietary supplement formulations. These combinations are designed to optimize metabolic pathways through synergistic coenzyme activity, enhancing both anti-fatigue and neuroprotective effects. As with any supplement, it is advisable to follow product guidelines and consult a healthcare professional before use.
    Q Who can benefit most from Bisbentiamine supplementation?
    Several groups may benefit from Bisbentiamine supplementation, including individuals with high blood sugar or diabetic complications, people experiencing fatigue or high physical exertion, those with vitamin B1 deficiency due to alcoholism or malnutrition, and individuals looking to support their nervous system and overall metabolic health.
    Q What are the recommended storage conditions for Bisbentiamine?
    Bisbentiamine should be stored at room temperature, away from direct light and moisture. Its melting point ranges from 140–145 °C, and it has a density of 1.331 g/cm³. Proper storage conditions help maintain its chemical stability and ensure the efficacy of the compound over time.