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Bisbentiamine Suppliers in China - High-Quality Thiamine Disulfide from Trusted Factory
Basic Information and Chemical Properties
Bisbentiamine (CAS No. 2667-89-2) is a derivative of vitamin B1 (thiamine), with the chemical name of dibenzoyl disulfide thiamine. Its structural feature is that two benzoyl groups are connected by a disulfide bond, which gives it unique fat solubility and stability.
CAS Number
2667-89-2
Molecular Formula
C₃₈H₄₂N₈O₆S₂
Molecular Weight
770.92
Density
1.331 g/cm³
Melting Point
140 – 145 °C
Boiling Point
987.4 °C (predicted)
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Storage Note: Must be stored away from light and moisture at room temperature to maintain stability and potency.
Functional Mechanism and Nutritional Health Effects
As a derivative of vitamin B1, bisbenzylthiamine has multiple potentials in the field of nutritional supplementation by optimizing bioavailability:
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1Enhanced BioavailabilityCompared with water-soluble thiamine, its fat-soluble structure is easier to pass through the cell membrane, improving absorption efficiency, thereby increasing the level of active coenzymes such as thiamine pyrophosphate (TPP) in the body, supporting energy metabolism and nervous system function.
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2Regulating Sugar Metabolism and Anti-OxidationBy activating transketolase, it promotes the normalization of glucose metabolism and reduces the accumulation of advanced glycation end products (AGEs), thereby combating oxidative damage and diabetic complications (such as neuropathy and retinopathy) caused by hyperglycemia.
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3Synergistic EffectSome dietary supplements combine it with other B vitamins (such as thiamine sulfozincate) to optimize metabolic pathways and enhance anti-fatigue and neuroprotective effects through the synergistic effect of coenzyme forms.
Application Scenarios and Product Examples
The application of bisbenzamide in dietary supplements is mainly concentrated in the following directions:
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1Diabetes and Metabolic HealthFor people with high blood sugar, it protects blood vessels and nerve tissues by inhibiting the formation of AGEs, and is often used to prevent complications such as diabetic neuropathy.
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2Energy Metabolism and Anti-FatigueAs a coenzyme, it participates in the tricarboxylic acid cycle and promotes the conversion of carbohydrates into energy. It is suitable for people with high physical exertion or easy fatigue.
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3Nervous System SupportImprove vitamin B1 deficiency caused by alcoholism or malnutrition, and maintain nerve conduction function.
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Bisbentiamine has become a popular ingredient in the field of nutritional supplements due to its high
bioavailability and multiple metabolic regulation functions. However, its application still needs to be combined
with individual needs and scientifically supplemented on the basis of a balanced diet. In the future, with the
advancement of synthetic biology technology and the deepening of clinical research, the potential of this
ingredient in the field of chronic disease prevention and precision nutrition will be further released.
Frequently Asked Questions (FAQ)
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What is Bisbentiamine and how does it differ from regular Vitamin B1?
Bisbentiamine (CAS No. 2667-89-2) is a fat-soluble derivative of vitamin B1 (thiamine). Unlike regular
water-soluble thiamine, its fat-soluble structure — formed by two benzoyl groups connected via a disulfide bond
— allows it to pass through cell membranes more efficiently, resulting in significantly higher bioavailability
and more stable absorption.
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How does Bisbentiamine support blood sugar and metabolic health?
Bisbentiamine activates the enzyme transketolase, which plays a key role in normalizing glucose metabolism. It
helps reduce the accumulation of advanced glycation end products (AGEs) — harmful compounds formed under
high-blood-sugar conditions — thereby protecting blood vessels and nerve tissues from oxidative damage and
diabetic complications.
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Who can benefit most from Bisbentiamine supplementation?
Bisbentiamine is particularly beneficial for individuals with high blood sugar levels or diabetes (to help
prevent neuropathy and retinopathy), people experiencing chronic fatigue or high physical exertion, those with
vitamin B1 deficiency due to alcoholism or malnutrition, and anyone seeking enhanced nervous system support and
improved energy metabolism.
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Can Bisbentiamine be combined with other B vitamins?
Yes. Bisbentiamine is often combined with other B vitamins, such as thiamine sulfozincate, in dietary
supplement formulations. This synergistic approach optimizes metabolic pathways and may enhance anti-fatigue and
neuroprotective benefits through complementary coenzyme activities.
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What are the key physical and chemical properties of Bisbentiamine?
Bisbentiamine has a molecular formula of C₃₈H₄₂N₈O₆S₂ and a molecular weight of 770.92. Its density is 1.331
g/cm³, melting point is 140–145 °C, and predicted boiling point is 987.4 °C. It should be stored at room
temperature, away from light and moisture, to ensure its stability.
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What is the future outlook for Bisbentiamine in nutrition and healthcare?
With continued advancements in synthetic biology and growing clinical research, Bisbentiamine holds strong
promise in the fields of chronic disease prevention and precision nutrition. Its high bioavailability and
multi-pathway metabolic regulation make it an increasingly valuable ingredient in next-generation functional
foods and dietary supplements.