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Bisbentiamine Suppliers and Factory in China - Thiamine Disulfide Derivative with CAS 2667-89-2
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Bisbentiamine Suppliers and Factory in China - Thiamine Disulfide Derivative with CAS 2667-89-2

Bisbentiamine (CAS No. 2667-89-is a highly regarded derivative of vitamin B1 (thiamine), known scientifically as dibenzoyl disulfide thiamine. This compound features the molecular formula C₃₈H₄₂N₈O₆S₂ and possesses a molecular weight of 770.9As a trusted product from leading suppliers in China, our factory ensures the highest quality standards in the production of Bisbentiamine, catering to the needs of various industries seeking reliable vitamin B1 derivatives.

    Basic Information and Chemical Properties

    Bisbentiamine (CAS No. 2667-89-2) is a derivative of vitamin B1 (thiamine), with the chemical name of dibenzoyl disulfide thiamine, the molecular formula of C₃₈H₄₂N₈O₆S₂, and a molecular weight of 770.92. Its structural feature is that two benzoyl groups are connected by a disulfide bond, which gives it unique fat solubility and stability.

    CAS Number
    2667-89-2
    Molecular Formula
    C₃₈H₄₂N₈O₆S₂
    Molecular Weight
    770.92
    Density
    1.331 g/cm³
    Melting Point
    140–145 °C
    Boiling Point
    987.4 °C (predicted)
    Storage Notice: Must be stored away from light and moisture at room temperature to maintain stability.
    Functional Mechanism and Nutritional Health Effects

    As a derivative of vitamin B1, bisbenzylthiamine has multiple potentials in the field of nutritional supplementation by optimizing bioavailability:

    • 1
      Enhanced Bioavailability

      Compared with water-soluble thiamine, its fat-soluble structure is easier to pass through the cell membrane, improving absorption efficiency, thereby increasing the level of active coenzymes such as thiamine pyrophosphate (TPP) in the body, supporting energy metabolism and nervous system function.

    • 2
      Regulating Sugar Metabolism and Anti-Oxidation

      By activating transketolase, it promotes the normalization of glucose metabolism and reduces the accumulation of advanced glycation end products (AGEs), thereby combating oxidative damage and diabetic complications (such as neuropathy and retinopathy) caused by hyperglycemia.

    • 3
      Synergistic Effect

      Some dietary supplements combine it with other B vitamins (such as thiamine sulfozincate) to optimize metabolic pathways and enhance anti-fatigue and neuroprotective effects through the synergistic effect of coenzyme forms.

    Application Scenarios and Product Examples

    The application of bisbenzamide in dietary supplements is mainly concentrated in the following directions:

    • 1
      Diabetes and Metabolic Health

      For people with high blood sugar, it protects blood vessels and nerve tissues by inhibiting the formation of AGEs, and is often used to prevent complications such as diabetic neuropathy.

    • 2
      Energy Metabolism and Anti-Fatigue

      As a coenzyme, it participates in the tricarboxylic acid cycle and promotes the conversion of carbohydrates into energy. It is suitable for people with high physical exertion or easy fatigue.

    • 3
      Nervous System Support

      Improve vitamin B1 deficiency caused by alcoholism or malnutrition, and maintain nerve conduction function.

    Bisbenzamide has become a popular ingredient in nutritional supplements due to its high bioavailability and multiple metabolic regulation functions. However, its application still needs to be combined with individual needs and scientifically supplemented on the basis of a balanced diet. In the future, with the advancement of synthetic biology technology and the deepening of clinical research, the potential of this ingredient in the field of chronic disease prevention and precision nutrition will be further released.
    Frequently Asked Questions (FAQ)
    Q What is Bisbentiamine and how does it differ from regular Vitamin B1?
    Bisbentiamine (CAS No. 2667-89-2) is a fat-soluble derivative of vitamin B1 (thiamine). Unlike regular water-soluble thiamine, its structural feature — two benzoyl groups connected by a disulfide bond — allows it to pass through cell membranes more efficiently, resulting in significantly higher bioavailability and better absorption by the body.
    Q How does Bisbentiamine support energy metabolism?
    As a coenzyme, Bisbentiamine participates in the tricarboxylic acid (TCA) cycle, promoting the efficient conversion of carbohydrates into usable energy. It also raises levels of thiamine pyrophosphate (TPP), a key active coenzyme involved in energy production, making it particularly beneficial for individuals with high physical demands or those who experience fatigue easily.
    Q Can Bisbentiamine help people with diabetes or high blood sugar?
    Yes. Bisbentiamine helps activate transketolase, an enzyme that promotes normal glucose metabolism and reduces the accumulation of advanced glycation end products (AGEs). This mechanism helps protect blood vessels and nerve tissues, making it useful in combating complications associated with hyperglycemia, such as diabetic neuropathy and retinopathy.
    Q Who can benefit most from Bisbentiamine supplementation?
    Bisbentiamine is most beneficial for individuals with high physical exertion, people experiencing fatigue, those with vitamin B1 deficiency due to alcoholism or malnutrition, individuals with elevated blood sugar levels or metabolic concerns, and those seeking neuroprotective support. As always, supplementation should be tailored to individual needs alongside a balanced diet.
    Q How should Bisbentiamine be stored to maintain its effectiveness?
    Bisbentiamine should be stored at room temperature, away from light and moisture. Exposure to humidity or direct light can compromise its chemical stability and reduce its effectiveness. Always keep it in a sealed, dry container in a cool, dark location.
    Q Is Bisbentiamine commonly combined with other B vitamins in supplements?
    Yes. Many dietary supplement formulations combine Bisbentiamine with other B vitamins — such as thiamine sulfozincate — to optimize metabolic pathways. The synergistic effect of these coenzyme forms helps enhance anti-fatigue properties and provides broader neuroprotective benefits, making combination formulas a popular choice in the nutritional supplement market.