Bisbentiamine / Bithiamin / Thiamine disulfide / Benzoylthiamine disulfide

Bisbentiamine (CAS No. 2667-89-2) is a derivative of vitamin B1 (thiamine), with the chemical name of dibenzoyl disulfide thiamine, the molecular formula of C₃₈H₄₂N₈O₆S₂, and a molecular weight of 770.92. Its structural feature is that two benzoyl groups are connected by a disulfide bond, which gives it unique fat solubility and stability. In terms of physical properties, the density is 1.331 g/cm³, the melting point is 140-145℃, and the boiling point is 987.4℃ (predicted value). It needs to be stored away from light and moisture at room temperature.

As a derivative of vitamin B1, bisbenzylthiamine has multiple potentials in the field of nutritional supplementation by optimizing bioavailability:

 

1. Enhanced bioavailability:

Compared with water-soluble thiamine, its fat-soluble structure is easier to pass through the cell membrane, improving absorption efficiency, thereby increasing the level of active coenzymes such as thiamine pyrophosphate (TPP) in the body, supporting energy metabolism and nervous system function.

 

2. Regulating sugar metabolism and anti-oxidation:

By activating transketolase, it promotes the normalization of glucose metabolism and reduces the accumulation of advanced glycation end products (AGEs), thereby combating oxidative damage and diabetic complications (such as neuropathy and retinopathy) caused by hyperglycemia.

 

3. Synergistic effect:

Some dietary supplements combine it with other B vitamins (such as thiamine sulfozincate) to optimize metabolic pathways and enhance anti-fatigue and neuroprotective effects through the synergistic effect of coenzyme forms.

The application of bisbenzamide in dietary supplements is mainly concentrated in the following directions:

 

1. Diabetes and metabolic health:

For people with high blood sugar, it protects blood vessels and nerve tissues by inhibiting the formation of AGEs, and is often used to prevent complications such as diabetic neuropathy.

 

2. Energy metabolism and anti-fatigue:

As a coenzyme, it participates in the tricarboxylic acid cycle and promotes the conversion of carbohydrates into energy. It is suitable for people with high physical exertion or easy fatigue.

 

3. Nervous system support:

Improve vitamin B1 deficiency caused by alcoholism or malnutrition, and maintain nerve conduction function.

 

Dieselamide has become a popular ingredient in the field of nutritional supplements due to its high bioavailability and multiple metabolic regulation functions. However, its application still needs to be combined with individual needs and scientifically supplemented on the basis of a balanced diet. In the future, with the advancement of synthetic biology technology and the deepening of clinical research, the potential of this ingredient in the field of chronic disease prevention and precision nutrition will be further released