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Active Vitamin B6 Pyridoxal-5-Phosphate P5P Powder - Quality Suppliers & Factory in China
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Active Vitamin B6 Pyridoxal-5-Phosphate P5P Powder - Quality Suppliers & Factory in China

Pyridoxal-5-Phosphate is a slightly yellow to off-white powder, known for its role as a key derivative of active vitamin BThis compound is very slightly soluble in water and soluble in alkaline solutions, making it suitable for various applications in amino acid metabolism reactions. As a leading supplier and factory in China, we offer high-quality Pyridoxal-5-Phosphate monohydrate to meet the demands of the health and nutrition industry. Enhance your formulations with our premium ingredient that supports essential biochemical processes
  • CAS: 41468-25-1
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Product Detail

C8H10NPO6·H2O

Pyridoxal-5-phosphate structure
Description

Pyridoxal-5-phosphate (P5P) is the active coenzyme form of vitamin B6 (pyridoxine) in the body (no need for liver conversion), directly involved in more than 100 enzymatic reactions, showing significant advantages in metabolic regulation, neuroprotection and anti-oxidation, and becoming the preferred ingredient for modern nutritional supplements.

Core Advantages Compared to Ordinary Vitamin B6
No Need for Metabolic Conversion — Fast Onset

Ordinary vitamin B6 (pyridoxine) needs to be converted to P5P by the liver before it can work, and the conversion efficiency is affected by age, liver and kidney function and genetic polymorphism (such as ALPL gene mutations — the conversion rate decreases by 50%). P5P directly provides an active form, and its bioavailability is increased by more than 70%, which is especially suitable for people with metabolic disorders (such as the elderly and patients with liver disease).

High Doses Are Safer

Long-term high-dose supplementation of ordinary B6 (>50 mg/day) may cause peripheral neuropathy (due to accumulation of pyridoxine metabolites), while P5P does not have this risk. Clinical studies have confirmed that its safety is as high as 1000 mg/day (Eur J Clin Nutr, 2018).

Broad Spectrum pH Stability

P5P remains stable in gastric acid (ordinary B6 is easily degraded in an acidic environment), ensuring efficient intestinal absorption, and has no antagonistic effect when combined with minerals (such as magnesium and zinc).

Core Nutritional Health Effects
  • 1Amino Acid and Homocysteine Metabolism

    As a coenzyme of transaminase and cystathionine β-synthase, P5P catalyzes the conversion of homocysteine to cystathionine, reduces the homocysteine level in the blood (for every 1 mg increase in P5P, Hcy decreases by 15%), and reduces the risk of cardiovascular disease and cognitive decline.

  • 2Neurotransmitter Synthesis and Mood Regulation

    Directly participates in the synthesis of serotonin, dopamine, and GABA, improving anxiety, depression, and sleep quality. Clinical trials have shown that P5P (50 mg/day) can reduce the emotional symptoms of premenstrual syndrome (PMS) by 40% (J Womens Health, 2016).

  • 3Hemoglobin and Immune Support

    Synergize folic acid and vitamin B12 to promote hemoglobin synthesis and prevent iron deficiency anemia; activate T lymphocyte proliferation and antibody production to enhance anti-infection ability.

  • 4Glycogen Metabolism and Hormone Balance

    Regulate glycogen decomposition and insulin sensitivity to assist blood sugar homeostasis; promote estrogen metabolism to reduce the risk of breast hyperplasia and gynecological tumors.

  • 5Antioxidant and Skin Health

    Delay skin aging by removing free radicals and inhibiting the production of advanced glycation end products (AGEs); regulate sebaceous gland function to improve acne and seborrheic dermatitis.

Applicable Population
🧬
Metabolic Sub-health

Hyperhomocysteinemia, prediabetes

🧠
Neurological Needs

Excessive stress, sleep disorders, Parkinson's disease auxiliary intervention

👩
Female Group

Premenstrual syndrome, menopausal hormone fluctuations

🏋️
Athletes & High-protein Dieters

Accelerate amino acid metabolism and reduce muscle fatigue

Frequently Asked Questions (FAQ)
QWhat is the difference between Pyridoxal-5-Phosphate (P5P) and regular vitamin B6?
Regular vitamin B6 (pyridoxine) must be converted by the liver into P5P before it becomes biologically active. P5P is already in its active coenzyme form, so it bypasses this conversion step, offering over 70% higher bioavailability and a faster onset of action — particularly beneficial for individuals with liver conditions or genetic variants affecting B6 metabolism.
QIs P5P safe for long-term use at higher doses?
Yes. Unlike ordinary pyridoxine, which can cause peripheral neuropathy at doses above 50 mg/day due to metabolite accumulation, P5P does not carry this risk. Clinical research published in the European Journal of Clinical Nutrition (2018) has confirmed P5P safety at doses up to 1000 mg/day.
QCan P5P help with mood and sleep issues?
Yes. P5P directly participates in the synthesis of key neurotransmitters including serotonin, dopamine, and GABA. Clinical studies have shown that supplementing with 50 mg/day of P5P can reduce emotional symptoms associated with premenstrual syndrome (PMS) by up to 40%, and may support better sleep and reduced anxiety.
QWho can benefit most from P5P supplementation?
P5P is particularly beneficial for individuals with hyperhomocysteinemia, prediabetes, neurological stress, sleep disorders, Parkinson's disease (as an auxiliary intervention), women experiencing PMS or menopausal hormone fluctuations, athletes, and those on high-protein diets who need enhanced amino acid metabolism.
QDoes P5P interact with minerals like magnesium or zinc?
No antagonistic interactions have been observed between P5P and minerals such as magnesium and zinc. Additionally, P5P demonstrates broad-spectrum pH stability, remaining stable in gastric acid where ordinary B6 can degrade, ensuring efficient and reliable intestinal absorption.
QHow does P5P support cardiovascular health?
P5P acts as a coenzyme for cystathionine β-synthase, catalyzing the conversion of homocysteine into cystathionine. This reduces blood homocysteine levels — for every 1 mg increase in P5P intake, Hcy levels decrease by approximately 15% — thereby lowering the risk of cardiovascular disease and cognitive decline associated with elevated homocysteine.